It is seen as a chronic inflammatory condition of the joints commonly, with pain, swelling and erosion its typical manifestations. It is, however, a systemic disease with several extra-articular manifestations influencing the heart, vessels, lungs, pores and skin and eyes. In addition to significant disability from pain and joint damage, patients with rheumatoid arthritis have a significantly reduced life expectancy of between 3 and 18 years. Most research have identified coronary disease as the major cause of premature loss of life in people with rheumatoid arthritis..Cunningham, MD, and David Booth, MD, of the Centre for Virus Analysis and the Institute of Immunology and Allergy Study at Westmead Millennium Institute and the University of Sydney in Australia, note that if the results regarding the C21orf91 gene are confirmed, additional research may then begin to determine feasible therapeutic applications and if the same gene also is important in recurring genital herpes.. Breast, cervical cancer rates rising worldwide Breast cancer rates are increasing. Worldwide, the true number of new breasts cancer cases has elevated from about 641,000 in 1980 to at least one 1.6 million cases this past year, a new study says.