Further investigation, the researchers note, is needed to define its role in those diseases and other styles of cancer. The group analyzed the other main cannabinoid receptor also, CB2, and discovered no part for it in colorectal cancer. They also treated the mice with a CB1 antagonist, a substance that binds to the receptor but does not activate it. Mice with CB1 blocked this way also showed a rise in the number and size of polyps. A CB1 antagonist known as rimonabant happens to be marketed overseas for fat loss.Bottom line: no known medical therapy apart from these extreme procedures has been discovered to adequately reduce CP pain generally in most people – as yet. A report published in Gastroenterology, the official journal of the American Gastroenterological Association Institute, concludes for the first time that antioxidant supplements are effective in relieving pain and reducing levels of oxidative stress in sufferers with CP. In a placebo-controlled, double blind trial, 127 CP sufferers received either placebos or antioxidants. At the end of six months, those in the antioxidant group had experienced far fewer pain-filled times than those in the placebo group.