Arrowhead increases ownership in Calando’s outstanding equity to 79 percent Arrowhead Research Company today announced that it has invested $1 million in its majority owned subsidiary, Calando Pharmaceuticals, and converted approximately $8M of Calando debt to Arrowhead into equity. Arrowhead now owns approximately 79 percent of Calando’s excellent equity. These include proof of the 1st definitive systemic siRNA delivery and initial to show RNAi mediated knockdown of focus on mRNA and protein in humans.Charcot can’t be reversed, but its destructive effects can be halted if the complication can be detected early. The symptoms of Charcot foot suddenly appear. They consist of warm and red skin, swelling and pain. A person with diabetes who has a red, hot, swollen foot or ankle requires emergency health care because these can also be symptoms of deep vein thrombosis or contamination. Doctors state Charcot’s ambiguous symptoms can lead to misdiagnosis. Since sufferers don’t feel pain, doctors may presume the swelling is due to disease and prescribe antibiotics. Meanwhile the individual continues walking on a foot that’s collapsing.