Additionally, people who have a wine intolerance were much more likely to statement other food intolerances. The interpretation of Wigand et al. Is that these leads to not indicate a genuine allergy necessarily, but rather an intolerance to alcoholic beverages, biogenic amines, sulfites, or other ingredients.. Around 7 percent of adults have problems with an intolerance to wine Around seven % of adults suffer from an intolerance to wine. The authors evaluated 948 questionnaires which were came back from the 4000 sent out to randomly chosen people between the age range of 20 and 69 years. They discovered that women were more often affected by an intolerance to wine than men .Study 2 – – A multicenter, double-blind, placebo-controlled research of 88 individuals with PKU who taken care of immediately Kuvan in Study 1. After a washout period from Research 1, individuals were randomized similarly to either Kuvan 10 mg/kg/day time or placebo for 6 weeks. Efficacy was assessed by the mean switch in bloodstream Phe level from baseline to Week 6 in the Kuvan-treated group in comparison with the mean transformation in the placebo group. Outcomes: At baseline, the mean bloodstream Phe level was 843 umol/L in the Kuvan-treated group and 888 umol/L in the placebo group.